L11P (p.Leu11Pro) variant of IFNAR1 (Interferon alpha/beta receptor 1)
L11P (p.Leu11Pro) in IFNAR1 (Interferon alpha/beta receptor 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
L11P (p.Leu11Pro) variant details
- p.Leu11Pro
- ExAC rs767812473
- TOPMed rs767812473
- gnomAD rs767812473
- Missense
- Variant Prioritization Score for Impact Estimate 0.475
- REVEL 0.41
- MetaLR 0.45
- MetaSVM -0.48
- CADD 25.10
- PolyPhen-2 0.98
- SIFT 0.04
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available