G27R (p.Gly27Arg) variant of IFNAR1 (Interferon alpha/beta receptor 1)
G27R (p.Gly27Arg) in IFNAR1 (Interferon alpha/beta receptor 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
G27R (p.Gly27Arg) variant details
- p.Gly27Arg
- NCI-TCGA TCGA novel
- TOPMed rs1809048623
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.346
- REVEL 0.27
- MetaLR 0.59
- MetaSVM -0.47
- CADD 24.00
- PolyPhen-2 0.96
- SIFT 0.27
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available