H74Y (p.His74Tyr) variant of IDH2 (P48735)
H74Y (p.His74Tyr) in IDH2 (P48735) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes structural context.
H74Y (p.His74Tyr) variant details
- p.His74Tyr
- rs1163791289
- NCI-TCGA Cosmic COSV1003
- cosmic curated COSV10034
- TOPMed rs1163791289
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.277
- AlphaMissense 0.07
- MetaLR 0.06
- MetaSVM -0.77
- PolyPhen-2 0.00
- SIFT 1.00
- EVE 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available