D41E (p.Asp41Glu) variant of IDH2 (P48735)
D41E (p.Asp41Glu) in IDH2 (P48735) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
D41E (p.Asp41Glu) variant details
- p.Asp41Glu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.234
- REVEL 0.13
- CADD 18.10
- PolyPhen-2 0.00
- SIFT 0.72
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available