V35M (p.Val35Met) variant of IDH1 (O75874)
V35M (p.Val35Met) in IDH1 (O75874) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
V35M (p.Val35Met) variant details
- p.Val35Met
- rs781398075
- NCI-TCGA Cosmic COSV6164
- cosmic curated COSV61644
- ExAC rs781398075
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.574
- REVEL 0.45
- CADD 23.70
- PolyPhen-2 0.13
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available