ID3 (Q02535) variants and mutations

ID3 (also known as Q02535) is a human protein-coding gene encoding a DNA-binding protein inhibitor ID-3 protein. It restrains basic helix-loop-helix transcription factors and thereby helps control lymphocyte development, cell differentiation, and proliferation. Somatic inactivation is recurrent in Burkitt lymphoma and related B-cell cancers, where it contributes to abnormal growth programs. This analysis covers 390 ID3 variants and mutations. Of these, 81% have computational variant effect predictions. Disease context includes Burkitt lymphoma, lymphoma, and non-Hodgkin lymphoma. Example ID3 variants include K2K, A3T, and A3V.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable ID3 variants

Examples include K2K, A3T, A3V, A3A, L4R, L4V, L4L, S5I. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.