W6R (p.Trp6Arg) variant of ICOS (Inducible T-cell costimulator)
W6R (p.Trp6Arg) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
W6R (p.Trp6Arg) variant details
- p.Trp6Arg
- TOPMed rs1302371793
- gnomAD rs1302371793
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.13
- MetaLR 0.08
- MetaSVM -1.01
- CADD 21.80
- PolyPhen-2 0.01
- SIFT 0.19
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available