W6C (p.Trp6Cys) variant of ICOS (Inducible T-cell costimulator)
W6C (p.Trp6Cys) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, published literature, and structural context.
W6C (p.Trp6Cys) variant details
- p.Trp6Cys
- gnomAD 2-203936832-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.171
- REVEL 0.06
- MetaLR 0.10
- MetaSVM -0.98
- CADD 19.10
- PolyPhen-2 0.01
- SIFT 0.18
- Population evidence available
- Structural context available
- Literature evidence available