W6* (p.Trp6Ter) variant of ICOS (Inducible T-cell costimulator)
W6* (p.Trp6Ter) in ICOS (Inducible T-cell costimulator) is a protein-truncating change. Clinical records from EBI and UniProt describe it as pathogenic. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
W6* (p.Trp6Ter) variant details
- p.Trp6Ter
- rs2469780660
- ClinGen CA350139437
- ClinVar RCV002824878
- Pathogenic
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.422
- CADD 35.00
- EBI: Pathogenic
- UniProt: Pathogenic
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available