V75G (p.Val75Gly) variant of ICOS (Inducible T-cell costimulator)
V75G (p.Val75Gly) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
V75G (p.Val75Gly) variant details
- p.Val75Gly
- gnomAD 2-203955801-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.146
- REVEL 0.16
- MetaLR 0.07
- MetaSVM -0.96
- CADD 4.92
- PolyPhen-2 0.01
- SIFT 0.09
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available
- Literature evidence available