V48F (p.Val48Phe) variant of ICOS (Inducible T-cell costimulator)
V48F (p.Val48Phe) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.
V48F (p.Val48Phe) variant details
- p.Val48Phe
- gnomAD 2-203955719-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.257
- REVEL 0.14
- MetaLR 0.12
- MetaSVM -1.01
- CADD 22.30
- PolyPhen-2 0.79
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available