V17I (p.Val17Ile) variant of ICOS (Inducible T-cell costimulator)
V17I (p.Val17Ile) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
V17I (p.Val17Ile) variant details
- p.Val17Ile
- TOPMed rs1022059218
- Missense
- Variant Prioritization Score for Impact Estimate 0.139
- REVEL 0.04
- MetaLR 0.06
- MetaSVM -1.01
- CADD 10.60
- PolyPhen-2 0.03
- SIFT 0.47
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available