T74S (p.Thr74Ser) variant of ICOS (Inducible T-cell costimulator)
T74S (p.Thr74Ser) in ICOS (Inducible T-cell costimulator) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, published literature, and structural context.
T74S (p.Thr74Ser) variant details
- p.Thr74Ser
- gnomAD 2-203955794-AAC-A
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.527
- CADD 20.60
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available