T74I (p.Thr74Ile) variant of ICOS (Inducible T-cell costimulator)
T74I (p.Thr74Ile) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, published literature, and structural context.
T74I (p.Thr74Ile) variant details
- p.Thr74Ile
- gnomAD 2-203955798-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.0816
- REVEL 0.04
- MetaLR 0.07
- MetaSVM -1.00
- CADD 1.51
- PolyPhen-2 0.08
- SIFT 0.12
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available
- Literature evidence available