T66A (p.Thr66Ala) variant of ICOS (Inducible T-cell costimulator)
T66A (p.Thr66Ala) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
T66A (p.Thr66Ala) variant details
- p.Thr66Ala
- gnomAD 2-203955773-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.165
- REVEL 0.07
- MetaLR 0.08
- MetaSVM -0.98
- CADD 13.40
- PolyPhen-2 0.16
- SIFT 0.34
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available