S93F (p.Ser93Phe) variant of ICOS (Inducible T-cell costimulator)
S93F (p.Ser93Phe) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
S93F (p.Ser93Phe) variant details
- p.Ser93Phe
- gnomAD 2-203955855-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.375
- REVEL 0.20
- MetaLR 0.17
- MetaSVM -0.81
- CADD 24.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available