S88Y (p.Ser88Tyr) variant of ICOS (Inducible T-cell costimulator)
S88Y (p.Ser88Tyr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
S88Y (p.Ser88Tyr) variant details
- p.Ser88Tyr
- cosmic curated COSV57030
- TOPMed rs1379505969
- gnomAD rs1379505969
- Missense
- Variant Prioritization Score for Impact Estimate 0.211
- REVEL 0.08
- MetaLR 0.12
- MetaSVM -0.98
- CADD 20.70
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available