S88F (p.Ser88Phe) variant of ICOS (Inducible T-cell costimulator)
S88F (p.Ser88Phe) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
S88F (p.Ser88Phe) variant details
- p.Ser88Phe
- gnomAD 2-203955840-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.191
- REVEL 0.08
- MetaLR 0.09
- MetaSVM -0.98
- CADD 13.90
- PolyPhen-2 0.02
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available