S88A (p.Ser88Ala) variant of ICOS (Inducible T-cell costimulator)
S88A (p.Ser88Ala) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
S88A (p.Ser88Ala) variant details
- p.Ser88Ala
- ExAC rs758698963
- TOPMed rs758698963
- gnomAD rs758698963
- Missense
- Variant Prioritization Score for Impact Estimate 0.2
- REVEL 0.06
- MetaLR 0.10
- MetaSVM -0.98
- CADD 19.50
- PolyPhen-2 0.28
- SIFT 0.03
- Most common in the South Asian population (allele frequency 4.6e-05)
- Structural context available