S71T (p.Ser71Thr) variant of ICOS (Inducible T-cell costimulator)
S71T (p.Ser71Thr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
S71T (p.Ser71Thr) variant details
- p.Ser71Thr
- ExAC rs760904375
- gnomAD rs760904375
- Missense
- Variant Prioritization Score for Impact Estimate 0.103
- REVEL 0.05
- MetaLR 0.04
- MetaSVM -1.05
- CADD 8.73
- PolyPhen-2 0.23
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available