S71R (p.Ser71Arg) variant of ICOS (Inducible T-cell costimulator)
S71R (p.Ser71Arg) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
S71R (p.Ser71Arg) variant details
- p.Ser71Arg
- gnomAD 2-203955790-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.123
- REVEL 0.08
- MetaLR 0.07
- MetaSVM -1.03
- CADD 8.96
- PolyPhen-2 0.49
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available