S3P (p.Ser3Pro) variant of ICOS (Inducible T-cell costimulator)
S3P (p.Ser3Pro) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
S3P (p.Ser3Pro) variant details
- p.Ser3Pro
- gnomAD rs1331888922
- Missense
- Variant Prioritization Score for Impact Estimate 0.229
- REVEL 0.01
- MetaLR 0.05
- MetaSVM -1.04
- CADD 7.61
- PolyPhen-2 0.01
- SIFT 0.21
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available