S25P (p.Ser25Pro) variant of ICOS (Inducible T-cell costimulator)
S25P (p.Ser25Pro) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
S25P (p.Ser25Pro) variant details
- p.Ser25Pro
- gnomAD rs1167660150
- Missense
- Variant Prioritization Score for Impact Estimate 0.386
- REVEL 0.15
- MetaLR 0.14
- MetaSVM -0.96
- CADD 22.60
- PolyPhen-2 0.57
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available