R14S (p.Arg14Ser) variant of ICOS (Inducible T-cell costimulator)
R14S (p.Arg14Ser) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from EBI and UniProt describe it as benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
R14S (p.Arg14Ser) variant details
- p.Arg14Ser
- 1000Genomes rs77411896
- ESP rs77411896
- ExAC rs77411896
- TOPMed rs77411896
- Benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.335
- REVEL 0.11
- MetaLR 0.06
- MetaSVM -1.07
- CADD 19.60
- PolyPhen-2 0.00
- SIFT 0.03
- EBI: Benign
- UniProt: Benign
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available