R14L (p.Arg14Leu) variant of ICOS (Inducible T-cell costimulator)
R14L (p.Arg14Leu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, published literature, and structural context.
R14L (p.Arg14Leu) variant details
- p.Arg14Leu
- gnomAD 2-203936855-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.142
- REVEL 0.04
- MetaLR 0.02
- MetaSVM -0.98
- CADD 8.80
- PolyPhen-2 0.00
- SIFT 0.13
- Population evidence available
- Structural context available
- Literature evidence available