Q50P (p.Gln50Pro) variant of ICOS (Inducible T-cell costimulator)
Q50P (p.Gln50Pro) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
Q50P (p.Gln50Pro) variant details
- p.Gln50Pro
- gnomAD 2-203955726-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.316
- REVEL 0.18
- MetaLR 0.18
- MetaSVM -0.62
- CADD 24.40
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available