Q50K (p.Gln50Lys) variant of ICOS (Inducible T-cell costimulator)
Q50K (p.Gln50Lys) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
Q50K (p.Gln50Lys) variant details
- p.Gln50Lys
- TOPMed rs1254587003
- Missense
- Variant Prioritization Score for Impact Estimate 0.346
- REVEL 0.19
- MetaLR 0.16
- MetaSVM -0.87
- CADD 24.30
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available