P45S (p.Pro45Ser) variant of ICOS (Inducible T-cell costimulator)
P45S (p.Pro45Ser) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
P45S (p.Pro45Ser) variant details
- p.Pro45Ser
- NCI-TCGA Cosmic COSV5703
- cosmic curated COSV57030
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.286
- REVEL 0.05
- MetaLR 0.05
- MetaSVM -1.04
- CADD 9.24
- PolyPhen-2 0.02
- SIFT 0.15
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available