P45L (p.Pro45Leu) variant of ICOS (Inducible T-cell costimulator)
P45L (p.Pro45Leu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, published literature, and structural context.
P45L (p.Pro45Leu) variant details
- p.Pro45Leu
- gnomAD 2-203955711-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.178
- REVEL 0.07
- MetaLR 0.11
- MetaSVM -1.02
- CADD 22.90
- PolyPhen-2 0.62
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available