N89T (p.Asn89Thr) variant of ICOS (Inducible T-cell costimulator)
N89T (p.Asn89Thr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
N89T (p.Asn89Thr) variant details
- p.Asn89Thr
- gnomAD 2-203955843-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.213
- REVEL 0.08
- MetaLR 0.08
- MetaSVM -0.85
- CADD 20.20
- PolyPhen-2 0.36
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available