N89S (p.Asn89Ser) variant of ICOS (Inducible T-cell costimulator)
N89S (p.Asn89Ser) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, published literature, and structural context.
N89S (p.Asn89Ser) variant details
- p.Asn89Ser
- gnomAD 2-203955843-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.184
- REVEL 0.05
- MetaLR 0.06
- MetaSVM -1.04
- CADD 17.70
- PolyPhen-2 0.05
- SIFT 0.05
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available