N35Y (p.Asn35Tyr) variant of ICOS (Inducible T-cell costimulator)
N35Y (p.Asn35Tyr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
N35Y (p.Asn35Tyr) variant details
- p.Asn35Tyr
- gnomAD 2-203955680-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.116
- REVEL 0.04
- MetaLR 0.07
- MetaSVM -1.04
- CADD 14.90
- PolyPhen-2 0.41
- SIFT 0.00
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available
- Literature evidence available