N35S (p.Asn35Ser) variant of ICOS (Inducible T-cell costimulator)
N35S (p.Asn35Ser) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
N35S (p.Asn35Ser) variant details
- p.Asn35Ser
- gnomAD rs1690065211
- Missense
- Variant Prioritization Score for Impact Estimate 0.222
- REVEL 0.05
- MetaLR 0.06
- MetaSVM -1.03
- CADD 13.50
- PolyPhen-2 0.09
- SIFT 0.15
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available