N35K (p.Asn35Lys) variant of ICOS (Inducible T-cell costimulator)
N35K (p.Asn35Lys) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
N35K (p.Asn35Lys) variant details
- p.Asn35Lys
- ESP rs201031378
- ExAC rs201031378
- TOPMed rs201031378
- gnomAD rs201031378
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.127
- REVEL 0.10
- MetaLR 0.04
- MetaSVM -1.12
- CADD 9.43
- PolyPhen-2 0.15
- SIFT 0.10
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available