N27K (p.Asn27Lys) variant of ICOS (Inducible T-cell costimulator)
N27K (p.Asn27Lys) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data, published literature, and structural context.
N27K (p.Asn27Lys) variant details
- p.Asn27Lys
- gnomAD 2-203955658-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.0859
- REVEL 0.05
- MetaLR 0.03
- MetaSVM -1.00
- CADD 1.41
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available