M53T (p.Met53Thr) variant of ICOS (Inducible T-cell costimulator)
M53T (p.Met53Thr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
M53T (p.Met53Thr) variant details
- p.Met53Thr
- gnomAD 2-203955735-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.11
- MetaLR 0.09
- MetaSVM -1.00
- CADD 23.00
- PolyPhen-2 0.11
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- Literature evidence available