M53I (p.Met53Ile) variant of ICOS (Inducible T-cell costimulator)
M53I (p.Met53Ile) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
M53I (p.Met53Ile) variant details
- p.Met53Ile
- Ensembl rs2105754139
- Missense
- Variant Prioritization Score for Impact Estimate 0.28
- REVEL 0.08
- MetaLR 0.05
- MetaSVM -1.06
- CADD 18.30
- PolyPhen-2 0.00
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available