L87I (p.Leu87Ile) variant of ICOS (Inducible T-cell costimulator)
L87I (p.Leu87Ile) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
L87I (p.Leu87Ile) variant details
- p.Leu87Ile
- gnomAD rs1266149006
- Missense
- Variant Prioritization Score for Impact Estimate 0.0998
- REVEL 0.07
- MetaLR 0.12
- MetaSVM -0.94
- CADD 2.02
- PolyPhen-2 0.60
- SIFT 0.09
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available