L80R (p.Leu80Arg) variant of ICOS (Inducible T-cell costimulator)
L80R (p.Leu80Arg) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
L80R (p.Leu80Arg) variant details
- p.Leu80Arg
- Ensembl rs865976515
- Missense
- Variant Prioritization Score for Impact Estimate 0.0835
- REVEL 0.05
- MetaLR 0.04
- MetaSVM -1.01
- CADD 0.07
- PolyPhen-2 0.12
- SIFT 0.55
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available