L80M (p.Leu80Met) variant of ICOS (Inducible T-cell costimulator)
L80M (p.Leu80Met) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
L80M (p.Leu80Met) variant details
- p.Leu80Met
- ExAC rs765794352
- TOPMed rs765794352
- gnomAD rs765794352
- Missense
- Variant Prioritization Score for Impact Estimate 0.0898
- REVEL 0.06
- MetaLR 0.06
- MetaSVM -1.03
- CADD 1.39
- PolyPhen-2 0.28
- SIFT 0.20
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available