L41I (p.Leu41Ile) variant of ICOS (Inducible T-cell costimulator)
L41I (p.Leu41Ile) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
L41I (p.Leu41Ile) variant details
- p.Leu41Ile
- gnomAD 2-203955698-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.124
- REVEL 0.03
- MetaLR 0.06
- MetaSVM -1.03
- CADD 9.77
- PolyPhen-2 0.01
- SIFT 0.59
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available