L41F (p.Leu41Phe) variant of ICOS (Inducible T-cell costimulator)
L41F (p.Leu41Phe) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
L41F (p.Leu41Phe) variant details
- p.Leu41Phe
- ExAC rs758752799
- gnomAD rs758752799
- Missense
- Variant Prioritization Score for Impact Estimate 0.124
- REVEL 0.06
- MetaLR 0.07
- MetaSVM -1.01
- CADD 13.70
- PolyPhen-2 0.49
- SIFT 0.23
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available