L18S (p.Leu18Ser) variant of ICOS (Inducible T-cell costimulator)
L18S (p.Leu18Ser) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
L18S (p.Leu18Ser) variant details
- p.Leu18Ser
- ExAC rs751851520
- gnomAD rs751851520
- Missense
- Variant Prioritization Score for Impact Estimate 0.381
- REVEL 0.34
- MetaLR 0.31
- MetaSVM -0.78
- CADD 22.50
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the South Asian population (allele frequency 0.0001)
- Structural context available