K69E (p.Lys69Glu) variant of ICOS (Inducible T-cell costimulator)
K69E (p.Lys69Glu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
K69E (p.Lys69Glu) variant details
- p.Lys69Glu
- ExAC rs773337402
- gnomAD rs773337402
- Missense
- Variant Prioritization Score for Impact Estimate 0.168
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.02
- CADD 14.60
- PolyPhen-2 0.02
- SIFT 0.18
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available