K43E (p.Lys43Glu) variant of ICOS (Inducible T-cell costimulator)
K43E (p.Lys43Glu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
K43E (p.Lys43Glu) variant details
- p.Lys43Glu
- gnomAD 2-203955704-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.19
- REVEL 0.09
- MetaLR 0.06
- MetaSVM -1.05
- CADD 19.40
- PolyPhen-2 0.30
- SIFT 0.11
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available