K2R (p.Lys2Arg) variant of ICOS (Inducible T-cell costimulator)
K2R (p.Lys2Arg) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
K2R (p.Lys2Arg) variant details
- p.Lys2Arg
- gnomAD 2-203936819-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.244
- REVEL 0.16
- MetaLR 0.16
- MetaSVM -0.88
- CADD 23.70
- PolyPhen-2 0.44
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available