K16E (p.Lys16Glu) variant of ICOS (Inducible T-cell costimulator)
K16E (p.Lys16Glu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
K16E (p.Lys16Glu) variant details
- p.Lys16Glu
- Ensembl rs1581596652
- Missense
- Variant Prioritization Score for Impact Estimate 0.158
- REVEL 0.07
- MetaLR 0.04
- MetaSVM -1.02
- CADD 7.89
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available