I61T (p.Ile61Thr) variant of ICOS (Inducible T-cell costimulator)
I61T (p.Ile61Thr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
I61T (p.Ile61Thr) variant details
- p.Ile61Thr
- gnomAD 2-203955759-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.121
- REVEL 0.04
- MetaLR 0.04
- MetaSVM -1.05
- CADD 9.22
- PolyPhen-2 0.12
- SIFT 0.49
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available