I61K (p.Ile61Lys) variant of ICOS (Inducible T-cell costimulator)
I61K (p.Ile61Lys) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
I61K (p.Ile61Lys) variant details
- p.Ile61Lys
- 1000Genomes rs199880572
- ExAC rs199880572
- gnomAD rs199880572
- Missense
- Variant Prioritization Score for Impact Estimate 0.137
- REVEL 0.07
- MetaLR 0.04
- MetaSVM -1.05
- CADD 7.36
- PolyPhen-2 0.39
- SIFT 0.96
- Most common in the 1KG:JPT population (allele frequency 0.0049)
- Structural context available