I32L (p.Ile32Leu) variant of ICOS (Inducible T-cell costimulator)
I32L (p.Ile32Leu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data, published literature, and structural context.
I32L (p.Ile32Leu) variant details
- p.Ile32Leu
- gnomAD 2-203955671-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.105
- REVEL 0.03
- MetaLR 0.07
- MetaSVM -1.03
- CADD 12.60
- PolyPhen-2 0.00
- SIFT 0.33
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available